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Spina bifida in Saudi Arabia: Is Consanguinity among the Parents a Risk Factor?
Waleed R. Murshid Department of Surgery, King Khalid University Hospital, Riyadh, Saudi Arabia Abstract
Introduction: Spina bifida is an important birth defect. Its incidence differs from one country to another due to different factors. The aims of this study were: (1) to estimate the incidence of spina bifida in Al-Madinah Al-Munawarah and compare it with the Eastern part of the Kingdom, and (2) to find out if consanguinity is a risk factor. Methodology: A prospective study was conducted over the period from April 1996 to March 1997 in the city of Al-Madinah Al-Munawarah, Western Province, Saudi Arabia. New cases of spina bifida were studied and compared to a control group of 72 cases. Results: During the study period, 18 cases of spina bifida were detected. The incidence was 1.09 per 1,000 live births. The male to female ratio was 2:1; however, this was not statistically significant. Consanguinity of the parents was found in 89% of the spina bifida parents and only 67% of the controls (p < 0.0005). Conclusion: (1) The incidence of spina bifida in the city of Al-Madinah Al-Munawarah was similar to that reported from the Eastern Province of Saudi Arabia. (2) The consanguinity of the parents was a significant risk factor. Pediatric Neurosurgery 2000;32:10-12 (DOI: 10.1159/000028890)
Vol. 32, No. 1, 2000 Dr. Waleed R. Murshid, FRCSEd (SN), FACS
Department of Surgery 37, King Khalid University Hospital
PO Box 7805
Riyadh 11472 (Kingdom of Saudi Arabia)
Fax +966 1 467 94 93, E-Mail $2wmurshid@ksu.edu.sa |
